Answer
$1$
Work Step by Step
Recall:
(1) ${n\choose j}=\dfrac{n!}{(n-j)!j!}$.
(2) $0!=1$
Hence, \begin{align*} \require{cancel}
{1000\choose 0}&=\dfrac{1000!}{(1000-0)!0!}\\ &=\dfrac{1000!}{1000!0!}\\ &=\dfrac{1000!}{1000!}\\ &=1\end{align*}