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By a "hook" do you mean something in your introduction to attract the reader? I'm not sure this is necessary if you are doing an academic expository. Still , here is my take on the relationship:

George has to look out for Lennie and take care of...

Auggie suffers with Treacher Collins Syndrome.

From the text:

“He is at present reported from Leicester, Nottingham, Southampton, Derby, East Ham, Richmond, and fourteen other places. In three of them—East Ham, Leicester, and Liverpool—there is a clear case against him, and he has actually
been...