Answer
$16x^4-72x^2+81$
Work Step by Step
First we apply the Sum and Difference of Two terms:
$[(2x+3)(2x-3)]^2$
$=[(2x)^2-3^2]^2$
$=(4x^2-9)^2$
Then we apply the Square of a Binomial:
$(4x^2-9)^2$
$=(4x^2)^2-2(4x^2)(9)+9^2$
$=16x^4-72x^2+81.$