#### Answer

$32$

#### Work Step by Step

$\bf{\text{Solution Outline:}}$
Use the order of operations (PEMDAS - Parenthesis, Exponents, Multiplication/Division, Addition/Subtraction) to simplify the given expression, $
(-4-1)(-3-5)-2^3
.$
$\bf{\text{Solution Details:}}$
Simplifying the expression/s in parenthesis, the entire expression above becomes
\begin{array}{l}\require{cancel}
(-5)(-8)-2^3
.\end{array}
Simplifying the exponents, the expression above becomes
\begin{array}{l}\require{cancel}
(-5)(-8)-8
.\end{array}
Simplifying the product/quotient, the expression above becomes
\begin{array}{l}\require{cancel}
40-8
.\end{array}
Simplifying the sum/difference, the expression above becomes
\begin{array}{l}\require{cancel}
32
.\end{array}