Answer
$x=\frac{-16}{9}$.
Work Step by Step
Note that:
$8^{6+3x}=(2^3)^{6+3x}=2^{18+9x}$
$4=2^2$
Thus, the given equation is equivalent to:
$2^{18+9x}=2^2$.
The base is the same (and not 1), hence they are equal if the exponents are equal. Therefore
\begin{align*}
18+9x&=2\\
9x&=2-18\\
9x&=-16\\
\frac{9x}{9}&=\frac{-16}{9}\\
x&=-\frac{16}{9}
\end{align*}