Answer
$D(D^2+4)$ is the annihilator of $F(x)$
Work Step by Step
We have: $F(x)=\dfrac{1+ \cos 2x}{2}$
Re-write as: $F(x)=\dfrac{1}{2}+\dfrac{\cos 2x}{2}$
So, $D$ is the annihilator of $\dfrac{1}{2}$ and $D^2+4$ is the annihilator of $\dfrac{\cos 2x}{2}$.
Therefore, $D(D^2+4)$ is the annihilator of $F(x)$.