Answer
$D+3$ is the annihilator of $F(x)$,
Work Step by Step
We consider the function $F(x)=5e^{-3x}$
We are given that $D+3$ is the annihilator of $G(x)=e^{-3x}$
This implies that the $F(x)=5 G(x)$
Therefore, $D+3$ is the annihilator of $F(x)$,