Answer
$\sqrt 5$.
Work Step by Step
1. Let $sin^{-1}(\frac{2\sqrt 5}{5})=t$, we have $sin(t)=\frac{2\sqrt 5}{5}$ and $t$ in quadrant I.
2. Let $y=2\sqrt 5, r=5$, we have $x=\sqrt {5^2-(2\sqrt 5)^2}=\sqrt {5}$.
3. Thus $sec(sin^{-1}(\frac{2\sqrt 5}{5}))=sec(t)=\frac{r}{x}=\sqrt 5$.