#### Answer

$4x^2-16 = (4)~(x+2)~(x-2)$

#### Work Step by Step

The general form of factoring the difference of two squares is as follows:
$x^2-y^2 = (x+y)~(x-y)$
We can factor the expression by using the GCF and then factoring the difference of two squares:
$4x^2-16 = (4)(x^2-4)$
$4x^2-16 = (4)~(x+2)~(x-2)$