Answer
$(4x+5y)^2$
Work Step by Step
The square of a binomial sum is: $(A+B)^2=A^2+2AB+B^2$.
The square of a binomial difference is: $(A-B)^2=A^2-2AB+B^2$.
Hence here: $16x^2-40xy+25y^2=(4x)^2+2\cdot4x\cdot5y+(5y)^2=(4x+5y)^2$
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