Answer
$-20x^3y^3$
Work Step by Step
Using the $(r+1)$st term of the expansion of $(a+b)^n$, which is given by $\dfrac{n!}{r!(n-r)!}a^{n-r}b^r$, then the $
4
$th term of $
(x-y)^6
$ is
\begin{array}{l}
\dfrac{6!}{3!3!}x^{3}(-y)^3
\\\\=
-20x^3y^3
\end{array}