Answer
$4x^{2}-16y^{2}$
Work Step by Step
Using the product of sum and difference of two terms $(a+b)(a-b)=a^{2}-b^{2}$,
$(2x-4y)(2x+4y)=(2x)^{2}-(4y)^{2}=4x^{2}-16y^{2}$.
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