Answer
$z_x=8xy^3e^{x^2y^3}$
$z_y=12x^2y^2e^{x^2y^3}$
Work Step by Step
Take the first partial derivatives of the given function. When taking partial derivative with respect to x, treat y as a constant, and vice versa:
$z_x=4e^{x^2y^3}*2xy^3=8xy^3e^{x^2y^3}$
$z_y=4e^{x^2y^3}*3x^2y^2=12x^2y^2e^{x^2y^3}$