Answer
$4x^{2}(9-\pi)$
Work Step by Step
The area of a square = $($side length$)^{2}$
The area of a circle = $\pi\cdot($radius$)^{2}$
Shaded area = (area of square) - (area of circle)
$=(6x)^{2}-\pi\cdot(2x)^{2}$
$=36x^{2}-\pi\cdot 4x^{2}$
GCF of the terms is $4x^{2}$. Use the distributive property to factor:
$=4x^{2}\cdot 9-4x^{2}\cdot\pi$
$=4x^{2}(9-\pi)$