Answer
$-90x^2$
Work Step by Step
Recall:
For real numbers $\sqrt[n]{a}$ and $\sqrt[n]{b}$,
$$\sqrt[n]{a} \cdot \sqrt[n]{b} = \sqrt[n]{ab}$$
Thus,
\begin{align*}
-5\sqrt{6x} \cdot 3\sqrt{6x^3}&=-5(3)\sqrt{6x \cdot 6x^3}\\
&=-15\sqrt{6^2x^4}\\
&=-15\sqrt{\left(6x^2\right)^2}\\
&=-15 \cdot 6x^2\\
&=-90x^2
\end{align*}