Answer
$\text{F}$
Work Step by Step
Recall:
$\sqrt[n]{a}=a^{\frac{1}{n}}$
Thus,
\begin{align*}
\sqrt[6]{81x^4y^8}&=\left(81x^4y^8\right)^{\frac{1}{6}}\\
&=\left(3^4x^4\cdot (y^2)^4\right)^{\frac{1}{6}}\\
&=\left[\left(3xy^2\right)^4\right]^{\frac{1}{6}}\\
&=\left(3xy^2\right)^{\frac{4}{6}}\\
&=\left(3xy^2\right)^{\frac{2}{3}}\\
\end{align*}
Thus, the answer is Option F.