As a generous patron of the arts, Marguerite befriended and protected many artists and writers, among them François Rabelais (1483–1553), Clément Marot (1496–1544), Claude de Bectoz (1490–1547), Pierre de Ronsard (1524–1585) and Julián Íñiguez de Medrano (1520's-1585-1588). Also, Marguerite served as a mediator between Roman Catholics and Protestants (including John Calvin). Although Marguerite espoused reform within the Catholic Church, she was not a Calvinist. She did, however, do her best to protect the reformers and dissuaded Francis I from intolerant measures as long as she could. After her death, eight religious wars occurred in France, including the notorious St. Bartholomew's Day Massacre of 1572.
Clos Lucé in Amboise, France, where Leonardo da Vinci died in 1519Leonardo da Vinci (1452–1519) died while guest of Marguerite and her brother, Francis I. They had been raised at Château d'Amboise, which belonged to their mother, Louise of Savoy. The king maintained his residence there and Marguerite maintained a residence nearby. During the first few years of the reign of Francis the château in which he lived reached the pinnacle of its glory. Leonardo had been the architect of a large château for them, among many other projects, and they provided quarters for him when he left Italy and joined her court. As a guest of the king, who provided him with a comfortable stipend, Leonardo da Vinci came to Château Amboise in December 1515 and lived and worked in the nearby Clos Lucé, connected to the château by an underground passage. Tourists are told that he is buried in the Chapel of Saint-Hubert, adjoining the Château, which had been built in 1491–96.[17]