At the age of seventeen Marguerite was married to Charles IV of Alençon, aged twenty, by the decree of King Louis XII (who also arranged the marriage of his ten-year-old daughter, Claude, to Francis). With this decree, Marguerite was forced to marry a generally kind but practically illiterate man for political expediency—"the radiant young princess of the violet-blue eyes... had become the bride of a laggard and a dolt". She had been bartered to save the royal pride of Louis, by keeping the County of Armagnac in the family. There were no offspring from this marriage.
Following the example set by her mother, Marguerite became the most influential woman in France during her lifetime when her brother acceded to the crown as Francis I in 1515. Her salon, known as the "New Parnassus", became famous internationally.
After the death of Queen Claude, she took in her two nieces Madeleine and Marguerite, for whom she would continue to care during her second marriage.[7]