Shadowhunters
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Clarissa Adele "Clary" Fray: A young Shadowhunter who discovered her heritage and special abilities at a later age. Clary is now trying to take down her father, Valentine, who wants to destroy the Shadowhunters and Downworlders.
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Jonathan "Jace" Wayland: A Shadowhunter struggling with his identity after he discovered that his father, whom he thought was dead, is actually his enemy Valentine.
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Alexander "Alec" Lightwood: A Shadowhunter in a homosexual relationship with the warlock Magnus Bane. Their relationship challenges traditional norms in Shadowhunter society, leading to conflict within Alec's family who struggles to accept his choices.
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Isabelle "Izzy" Lightwood: Alec's sister who supports his relationship. She also helps Clary and Jace in the fight against Valentine.
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Valentine Morgenstern: A Shadowhunter who aims to destroy both Shadowhunters and Downworlders with the aid of the Mortal Instruments.
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Jocelyn Fray: Clary's mother who hid her heritage to protect her.
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Maryse Lightwood: Alec and Isabelle's mother who leads the New York Institute with her husband.
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Robert Lightwood: Alec and Isabelle's father who leads the New York Institute with his wife.
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Max Lightwood: The youngest child of the Lightwood family.
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Sebastian Verlac: A mysterious individual who meets Clary and the Lightwood family in Alicante.
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Aline Penhallow: A friend of the Lightwoods and the cousin of Sebastian Verlac.
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Amatis Herondale: Luke's sister who lives in isolation in Idris.
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Inquisitor Aldertree: The new Inquisitor who is willing to lie and manipulate the truth to close a case.
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Madeleine Bellefleur: Jocelyn's friend, who claims to be able to awaken Jocelyn from her coma.
Downworlders
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Simon Lewis - Clary's best friend who was turned into a vampire.
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Magnus Bane - The High Warlock of Brooklyn, who reluctantly agrees to assist the Conclave to save Alec.
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Luke Garroway - Jocelyn and Clary's friend, he is a werewolf and a former Shadowhunter.
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Maia Roberts - A member of Luke's werewolf pack in New York.
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Raphael Santiago - The leader of the vampire clan of New York.
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Seelie Queen - The queen of the Seelie Court and of the Fair Folk.
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Meliorn - The queen's personal knight and confidante.
Angels
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Raziel - The patron Angel of the Nephilim.
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Ithuriel - An angel imprisoned by Valentine, who used his blood for his experiments.
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