Answer
Genes that promote or predispose to cancer development have been identified. They include the following examples:
a. BRCA1an the BRCA2 genes
b. RET--the retinoblastoma gene
We all inherit two copies of BRCA1 in each cell. If one of these alleles is mutant, then the possessor is at risk for developing cancer. If the second copy mutates, then the tumor suppressor action is lifted and cancer development is permitted--if not promoted. If the mutation occurs in the breast tissue, breast cancer develops; if it occurs in the ovary, ovarian cancer develops. BRCA1 and BRCA2 genes are named for their association with breast cancer, but they are found in other tissues.
The RB or retinoblastoma gene is associated with caner of the retina. . A single mutated copy is usually inherited. If the other allele mutates, retinoblastoma may develop in one or both eyes.
Work Step by Step
Genes that promote or predispose to cancer development have been identified. They include the following examples:
a. BRCA1an the BRCA2 genes
b. RET--the retinoblastoma gene
We all inherit two copies of BRCA1 in each cell. If one of these alleles is mutant, then the possessor is at risk for developing cancer. If the second copy mutates, then the tumor suppressor action is lifted and cancer development is permitted--if not promoted. If the mutation occurs in the breast tissue, breast cancer develops; if it occurs in the ovary, ovarian cancer develops. BRCA1 and BRCA2 genes are named for their association with breast cancer, but they are found in other tissues.
The RB or retinoblastoma gene is associated with caner of the retina. . A single mutated copy is usually inherited. If the other allele mutates, retinoblastoma may develop in one or both eyes.
