Answer
In mutant cells that cannot phosphorylate Rb, the protein would remain in an active, bound state, preventing E2F from promoting cell cycle progression.
Work Step by Step
. Rb (Retinoblastoma) is a tumor suppressor protein that plays a critical role in the regulation of the cell cycle by binding and inhibiting E2F transcription factors.
mutations that inactivate Rb completely would have the opposite effect, allowing the cells to bypass cell cycle checkpoints and continue dividing uncontrollably, which could lead to the development of cancer.
