Answer
Because the release of PDGF from platelets is so closely controlled and regulated, malignancies do not develop at wounds where it is released. PDGF is released by activated platelets at the site of a wound to encourage cell growth and division necessary for tissue repair. The PDGF release is strictly controlled by feedback systems that prevent excessive or protracted signaling, but it is only momentary..
Work Step by Step
At the location of a wound, the release of PDGF from platelets is carefully regulated and managed, preventing the out-of-control expression of the PDGF gene that can cause cancer. Instead of aberrant or altered cells that could potentially turn into cancer, PDGF stimulates normal cells that are needed for tissue repair at the site of a wound.
