Answer
Prokaryotes and eukaryotes are both types of cells, but their main difference is that prokaryotes do not have a membrane-bound nucleus, and eukaryotes do have a membrane-bound nucleus.
Work Step by Step
Eukaryotes separate their DNA in their nucleus, therefore having a membrane to keep this separation. Prokaryotes do not keep their genetic material separate, therefore not having a membrane to keep its separation from other cell components.