Answer
$${f_{xx}}\left( {x,y} \right) = 8{y^2} - 32,\,\,\,\,{f_{yy}}\left( {x,y} \right) = 8{x^2},\,\,\,\,{f_{xy}}\left( {x,y} \right) = 16xy,\,\,\,{f_{yx}}\left( {x,y} \right) = 16xy$$
Work Step by Step
$$\eqalign{
& f\left( {x,y} \right) = 4{x^2}{y^2} - 16{x^2} + 4y \cr
& \cr
& {\text{Find }}{f_x}\left( {x,y} \right){\text{ and }}{f_y}\left( {x,y} \right) \cr
& {f_x}\left( {x,y} \right) = \frac{\partial }{{\partial x}}\left[ {4{x^2}{y^2} - 16{x^2} + 4y} \right] \cr
& {\text{treat }}y{\text{ as a constant and }}x{\text{ as a variable}}{\text{. then}} \cr
& {f_x}\left( {x,y} \right) = \frac{\partial }{{\partial x}}\left[ {4{x^2}{y^2}} \right] - \frac{\partial }{{\partial x}}\left[ {16{x^2}} \right] + \frac{\partial }{{\partial x}}\left[ {4y} \right] \cr
& {f_x}\left( {x,y} \right) = 8x{y^2} - 32x \cr
& \cr
& {f_y}\left( {x,y} \right) = \frac{\partial }{{\partial y}}\left[ {4{x^2}{y^2} - 16{x^2} + 4y} \right] \cr
& {\text{treat }}x{\text{ as a constant and }}y{\text{ as a variable}}{\text{. then}} \cr
& {f_y}\left( {x,y} \right) = \frac{\partial }{{\partial y}}\left[ {4{x^2}{y^2}} \right] - \frac{\partial }{{\partial y}}\left[ {16{x^2}} \right] + \frac{\partial }{{\partial y}}\left[ {4y} \right] \cr
& {f_y}\left( {x,y} \right) = 8{x^2}y + 4 \cr
& \cr
& {\text{find the second - order partial derivatives}} \cr
& {f_{xy}}\left( {x,y} \right) = \frac{\partial }{{\partial y}}\left[ {8x{y^2} - 32x} \right] \cr
& {f_{xy}}\left( {x,y} \right) = 16xy \cr
& \cr
& {f_{yx}}\left( {x,y} \right) = \frac{\partial }{{\partial x}}\left[ {8{x^2}y + 4} \right] \cr
& {f_{yx}}\left( {x,y} \right) = 16xy \cr
& \cr
& {f_{xx}}\left( {x,y} \right) = \frac{\partial }{{\partial x}}\left[ {8x{y^2} - 32x} \right] \cr
& {f_{xx}}\left( {x,y} \right) = 8{y^2} - 32 \cr
& {\text{and}} \cr
& {f_{yy}}\left( {x,y} \right) = \frac{\partial }{{\partial y}}\left[ {8{x^2}y + 4} \right] \cr
& {f_{yy}}\left( {x,y} \right) = 8{x^2} \cr} $$