Answer
No
Work Step by Step
Let $v_1$ be vector in the line containing the first two points.
$v_1=\lt-1-(-2),1-4,1-0\gt$
$=\lt 3,-3,1\gt$
Let $v_2$ be vector in the line containing the second two points.
$v_2=\lt3-2,-1-3,-8-4\gt$
$=\lt 1,-4,-12\gt$
Dot product of two vectors: $\lt 3,-3,1\gt \cdot \lt 1,-4,-12\gt$
$=3(1)+(-3)(-4)+1(-12)$
$=3$
They are not perpendicular.