#### Answer

$2xy(x-4)(x+4)$

#### Work Step by Step

RECALL:
A difference of two squares can be factored using the formula:
$a^2-b^2=(a-b)(a+b)$
Factor out the greatest common factor, $2xy$, to obtain:
$=2xy(x^2-16)
\\=2xy(x^2-4^2)$
The binomial is a difference of two squares.
Factor the given difference of two squares using the formula above with $a=x$ and $b=4$ to obtain:
$=2xy(x-4)(x+4)$