Answer
$-\dfrac{1}{5}$.
Work Step by Step
Substitute $1$ for $x$ and $-2$ for $y$ in the expression:
$=\frac{2(1 + 5)(-2)}{10(1 - 4)(-2 - 2)}$
Follow order of operations and simplify what is in parentheses first:
$=\dfrac{2(6)(-2)}{10(-3)(-4)}$
Multiply from left to right, according to order of operations:
$=\dfrac{(12)(-2)}{(-30)(-4)}$
Multiply once again in both numerator and denominator:
$=\dfrac{-24}{120}$
Divide both numerator and denominator by $24$ to simplify this fraction:
$=-\dfrac{1}{5}$.