Answer
$12$
Work Step by Step
Substitute $1$ for $x$ and $-2$ for $y$ in the expression:
$=\dfrac{16(1 - 4)(-2 - 2)}{4(1 - 3)(-2)}$
Let us follow order of operations and simplify what is in parentheses first:
$=\dfrac{16(-3)(-4)}{4(-2)(-2)}$
Let us multiply from left to right, according to order of operations:
$=\dfrac{(-48)(-4)}{(-8)(-2)}$
Multiply once again in both numerator and denominator:
$=\dfrac{(192)}{(16)}$
$=12$