The series opens with the arrival of Mary Ann Singleton, a naive young woman from Cleveland, Ohio, who is visiting San Francisco on vacation when she impulsively decides to stay. She finds an apartment at 28 Barbary Lane, the domain of the eccentric, marijuana-growing landlady Anna Madrigal, later revealed to be a transgender woman. Mary Ann becomes friends with other tenants of the building: the hippyish, bisexual Mona Ramsey; heterosexual lothario Brian Hawkins; the sinister and cagey roof tenant Norman Neal Williams; and Michael Tolliver, a sweet and personable gay man known to friends as Mouse (as in Mickey).
Beyond the house, lovers and friends guide Mary Ann through her San Francisco adventures. Edgar Halcyon, Mary Ann's and Mona's boss; Edgar's socialite daughter DeDe Halcyon-Day (a character based on real-life art patron Dede Wilsey[3]); and DeDe's scheming bisexual husband Beauchamp Day all provide a glimpse into a more affluent Californian class. Mother Mucca, Mrs. Madrigal's mother and owner of the Blue Moon Lodge brothel, brings mystery and comic relief. D'orothea Wilson returns from a modeling assignment in New York to resume an affair with Mona. Jon Fielding, Michael's lover and DeDe's gynecologist, becomes part of the social group. Michael's lovers later in the series include Thack Sweeney and the significantly younger Ben McKenna.
