- Bill Murray as Bob Harris, a fading movie star
- Scarlett Johansson as Charlotte, a recent college graduate
- Giovanni Ribisi as John, Charlotte's husband, a celebrity photographer
- Anna Faris as Kelly, a Hollywood actress
- Fumihiro Hayashi as Charlie, Charlotte's friend
- Catherine Lambert as a jazz singer[note 2]
- Matthew Minami as himself[8][9]
- Fujiwara Hiroshi as unnamed party guest[10]
- Hiromix as nightclub guest and seen at the end of the credits roll[11]
- Yamaguchi Akira as hotel bellboy[12][13]
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