A central motif of the novel is that all actions have consequences and that it is impossible for an individual to stand aloof and be a mere observer of life, as Jack tries to do (first as a graduate student doing historical research and later as a wisecracking newspaperman). In the atmosphere of the 1930s, the whole population seemed to abandon responsibility by living vicariously through messianic political figures like Willie Stark. Thus, Stark fulfills the wishes of many of the characters, or seems to do so. For instance, his faithful bodyguard Sugar-Boy, who stutters, loves Stark because "the b-boss could t-talk so good", and Jack Burden cannot bring himself to sleep with Anne Stanton, whom he loves, although Stark does so. It is in that sense that the characters are "all the king's men", a line taken from the poem Humpty Dumpty (Warren biographer Joseph Blotner also notes, "Like Humpty Dumpty, each of the major characters has experienced a fall of some kind").[8] The title is derived from the motto of Huey P. Long, whose life was similar to that of Willie Stark, "Every Man a King", but that vicarious achievement will eventually fail. Jack ultimately realizes that one must "go out of history into history and the awful responsibility of Time".
The "Great Twitch" is a particular brand of nihilism that Jack embraces during his journey westward: "all the words we speak meant nothing and there was only the pulse in the blood and the twitch of the nerve, like a dead frog's leg in the experiment when the electric current goes through."[9] On his way back from California, Jack gives a ride to an old man who has an involuntary facial twitch. This image becomes for him the encapsulating metaphor for the idea that "all life is but the dark heave of blood and the twitch of the nerve."[10]
Subsequent events (including the tragic deaths of Governor Stark, Jack's lifelong friend Adam Stanton, and Judge Irwin, Jack's father) convince Jack that the revelation of the "Great Twitch" is an insufficient paradigm to explain what he has seen of history. "[H]e saw that though doomed, [his friends] had nothing to do with any doom under the godhead of the Great Twitch. They were doomed, but they lived in the agony of will."[11]
