Clive Barnes, in his review of the 1971 Off-Broadway production for The New York Times wrote: "You will have noticed, I presume, that comedy has taken on a hysterical edge. The laughter is manic, and the world is awry. Few worlds are more awry than John Guare's, whose play, 'The House of Blue Leaves,' opened last night at the Truck and Warehouse Theater. Mr. Guare's play is mad, funny, at times very funny, and sprawling."[9]
The Variety reviewer of the 2011 revival wrote: "Guare’s iconic play not only holds up, it still sets the bar for smart comic lunacy.... Guare is famous for the zany plots that illustrate his surreal visions of what passes for modern civilization.... But the key to the play lies beyond these apartment walls, in the broader framework of the unsettled period of the mid-Sixties, when America was still reeling from the assassination of JFK and just becoming aware of what was going on in Vietnam."[10]
