The play is set in Sunnyside, Queens, New York City, New York, in 1965, on the day Pope Paul VI visited. The black comedy focuses on Artie Shaughnessy, a zookeeper who dreams of making it big in Hollywood as a songwriter. Artie wants to take his girlfriend Bunny with him to Hollywood. His wife Bananas is a schizophrenic and destined for the institution that provides the play's title. Their son Ronnie, a GI scheduled for deployment to Vietnam, has gone AWOL. Three nuns are eager to see the pope and end up in Artie's apartment. A political bombing mistakenly occurs in the apartment.
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