- Emma Watson as Mae Holland
- Tom Hanks as Eamon Bailey
- John Boyega as Ty Lafitte
- Karen Gillan as Annie Allerton
- Ellar Coltrane as Mercer Regalado
- Patton Oswalt as Tom Stenton
- Bill Paxton as Vinnie Holland, Mae's father
- Glenne Headly as Bonnie Holland, Mae's mother
- Nate Corddry as Dan
- Mamoudou Athie as Jared
- Jimmy Wong as Mitch
- Ellen Wong as Renata
- Smith Cho as Gina
- Poorna Jagannathan as Dr. Jessica Villalobos
- Judy Reyes as Congresswoman Olivia Santos
- Eve Gordon as Senator Williamson
- Beck as himself
- Claudia O’Doherty as High Powered Circler
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