Answer
No.
Work Step by Step
Compression in a piston-cylinder device would occur at constant pressure, therefore: $V/T=constant$
Since the process is adiabatic: $Q=0 \rightarrow \Delta U=-W$
For there to be an isothermal compression the change in volume would need to be compensated by a change in temperature, therefore it is not possible for this process to also be isothermal.
