When the stomach is overfilled, the problems of gastric reflux arises, and the food may flow back into the esophagus.
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This can become a serious problem; gastric contents are very acidic ( PH 1.5-3.5). The epithelium of the stomach can resist the action of this acid chyme, but the epithelium of the esophagus is more delicate, and is easily damaged by strong acids. Chronic reflux of acid stomach contents may cause erosion of esophageal epithelium and can result in esophageal ulcers.