Human Anatomy & Physiology (9th Edition)

Published by Pearson
ISBN 10: 0321743261
ISBN 13: 978-0-32174-326-8

Chapter 24 - Nutrition, Metabolism, and Body Temperature Regulation - Review Questions - Critical Thinking and Clinical Application Questions - Page 952: 4


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Dinitrolphenol ( DNP ) and Weight Loss - DNP was one of the first anti-obesity therapy in the 1940 s. - it was shown to cause weight loss by increasing the rate of oxidation by uncoupling oxidation from the formation of high energy phosphate ( = phospharylation ) leads to generation of heat, leading to high Metabolic Rate and increased fat metabolism. - in presence of DNP, electron transport continue , even at a higher rate, but ATP production is decreased, the energy that should have been converted to chemical energy in the form of ATP is then released as excess heat ( = DNP uncouples the Chemiosomatic Machinery ). - DNP in a dose of 3-5 mg/kg. increases the Metabolic Rate more than 20% for 24-48 hours. if given chronically, a 50% elevation can be maintained. - in the past, it was used for the treatment of obesity but serious side effects lead to its withdrawal from use. ( = death of patients )
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