Vesalius went against the conventional thinking of following Galen and Aristotle's conclusions which everyone else followed religiously. He improved education by illustrating the anatomy in a way which had never been done before. He did not only improve medical standards by actually being involved in the process of dissection but improved the way people saw the anatomy. He started a new way of thinking by breaking tradition which would extend to his followers which would also now think in a new direction.
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I concluded this answer by using the diagrams provided in the book which were vivid illustrations and would have definitely had an impact at that time. As a single surgeon going against the conventional traditional way it must have made waves with his followers and other surgeons and medical professionals for years to come.