Answer
$8$
Work Step by Step
We are given: $x=-1$, $y=2$, $z=-3$
We take into account the order of operations:
Parenthesis, Exponents, Multiplication/Division, Addition/Subtraction
Thus, we have:
$$ (2x+6)(3y-4)=(2(-1)+6)(3(2)-4)\\
=(4)(2)=8
.$$