Answer
Domain = $\mathbb{R}\backslash\{-2\}$ or $\{x\in \mathbb{R}\ |\ x\neq-2\}$
Range = $\mathbb{R}\backslash\{-4\}$ or $\{y\in \mathbb{R}\ |\ y \neq-4\}$
Work Step by Step
If the function is described by a graph, then the domain is the set of all first coordinates of the points on the graph. The range is the set of all second coordinates.
The empty dot at $(-2,-4)$ indicates that the point does not belong to the graph.
The first coordinate of a point of the graph can be any real number, except -2.
Domain = $\mathbb{R}\backslash\{-2\}$ or $\{x\in \mathbb{R}\ |\ x\neq-2\}$,
The second coordinate can be any real number, except $-4$.
Range = $\mathbb{R}\backslash\{-4\}$ or $\{y\in \mathbb{R}\ |\ y \neq-4\}$