Answer
$-3$
Work Step by Step
The determinant of a $2\times2$ matrix $A=\begin{bmatrix}a & b\\c&d
\end{bmatrix}$ is given by $ad-bc.$ Hence, the determinant of the given matrix, $
\begin{bmatrix}
2&-1\\5&-4
\end{bmatrix}$ is
\begin{align*}\require{cancel}
&
2(-4)-5(-1)
\\&=
-8+5
\\&=
-3
.\end{align*}