- Harrison Ford as Indiana Jones: An archaeology professor and adventurer[4]
- Karen Allen as Marion Ravenwood: A spirited, tough bar owner and Jones' former lover[5]
- Paul Freeman as René Belloq: A rival archaeologist to Jones, in the employ of the Nazis[6]
- Ronald Lacey as Major Arnold Toht: A sadistic Gestapo agent[7]
- John Rhys-Davies as Sallah: An Egyptian excavator and old acquaintance of Jones[8]
- Denholm Elliott as Marcus Brody: A museum curator and Jones' loyal friend[8]
Raiders of the Lost Ark also features Wolf Kahler as Nazi officer Colonel Dietrich[9] and Anthony Higgins as Major Gobler, Dietrich's right-hand man.[10] Don Fellows and William Hootkins appear as United States Army Intelligence agents Colonel Musgrove and Major Eaton, respectively.[10][11][12] George Harris plays Simon Katanga, captain of the Bantu Wind tramp steamer,[13] and Fred Sorenson portrays Jones' pilot Jock.[14]
Producer Frank Marshall appears as the Flying Wing pilot.[10] Pat Roach appears as the Nazi who brawls with Jones by the Flying Wing and one of Toht's Nepalese Sherpas.[15] Vic Tablian plays Jones's treacherous Peruvian guide Barranca and the Monkey Man in Cairo.[15][16] The film features the first theatrical appearance of Alfred Molina as Jones' guide Satipo.[17] Terry Richards portrays the Cairo swordsman shot by Jones.[10][18]