- Julianne Moore as Cathleen "Cathy" Whitaker
- Dennis Quaid as Frank Whitaker
- Dennis Haysbert as Raymond Deagan
- Patricia Clarkson as Eleanor Fine
- Viola Davis as Sybil
- James Rebhorn as Dr. Bowman
- Celia Weston as Mona Lauder
- Michael Gaston as Stan Fine
- Ryan Ward as David Whitaker
- Lindsay Andretta as Janice Whitaker
- Jordan Puryear as Sarah Deagan
- Bette Henritze as Mrs. Leacock
- Barbara Garrick as Doreen
- Olivia Birkelund as Nancy
- June Squibb as Elderly Woman
- J.B. Adams as Morris Farnsworth
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