- East of Eden (band), a British progressive rock band, or a 1971 album by the band
- East of Eden (album), by Taken by Trees, 2009
- "East of Eden" (Big Country song), 1984
- "East of Eden" (Zella Day song), 2014
- "East of Eden", a song by Babyshambles, a B-side of the single "Fuck Forever", 2005
- "East of Eden", a song by Dead Can Dance from Dead Can Dance, 1984
- "East of Eden", a song by Lone Justice from Lone Justice, 1985
- "East of Eden", a song by Mason Jennings from Century Spring, 2002
- "East of Eden" a Japanese rock band
- "PTT (Paint the Town)", a song by Loona from &, 2021 in which the lyrics reference the East of Eden
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