There have been numerous adaptations of the novella, including over 120 stage and film versions alone.[32]
There have also been many audio recordings of the novella, with some of the more famous readers including Tom Baker, Roger Rees, Christopher Lee, Udo Kier, Anthony Quayle, Martin Jarvis, Tim Pigott-Smith, John Hurt, Ian Holm, Gene Lockhart, Richard Armitage, John Sessions, Alan Howard, Rory Kinnear and Richard E. Grant.
A 1990 musical based on the story was created by Frank Wildhorn, Steve Cuden, and Leslie Bricusse.
There have also been several video games based on the story, such as "Jekyll and Hyde", published by MazM.