- Jamie Foxx as Django Freeman
- Christoph Waltz as Dr. King Schultz
- Leonardo DiCaprio as "Monsieur" Calvin J. Candie
- Kerry Washington as Broomhilda "Hildi" von Shaft[1]
- Samuel L. Jackson as Stephen Warren
- Walton Goggins as Billy Crash
- Dennis Christopher as Leonide "Leo" Moguy
- James Remar as Butch Pooch / Ace Speck
- David Steen as Mr. Stonecipher
- Dana Gourrier as Cora
- Nichole Galicia as Sheba
- Laura Cayouette as Lara Lee Candie-Fitzwilly
- Ato Essandoh as D'Artagnan
- Sammi Rotibi as Rodney
- Clay Donahue Fontenot as Luigi
- Escalante Lundy as Big Fred
- Miriam F. Glover as Betina
- Don Johnson as Spencer "Big Daddy" Bennett
- Franco Nero as Amerigo Vessepi
Other roles include: James Russo as Dicky Speck, brother of Ace Speck and erstwhile owner of Django; Tom Wopat, Omar J. Dorsey, and Don Stroud play U.S. Marshal Gill Tatum, Chicken Charlie, and as Sheriff Bill Sharp respectively; Bruce Dern appears as Old Man Carrucan, the owner of the Carrucan Plantation; M. C. Gainey, Cooper Huckabee, and Doc Duhame portray brothers Big John Brittle, Roger "Lil Raj" Brittle, and Ellis Brittle respectively, overseers of both Carrucan and Big Daddy's plantations.
Jonah Hill plays Bag Head #2, a member of Bennett's masked white supremacist group. Additional roles include Lee Horsley as Sheriff Gus, Rex Linn as Tennessee Harry, Misty Upham as Minnie, and Danièle Watts as Coco. Russ Tamblyn and his daughter Amber appear as townspeople in Daugherty, Texas; their roles are respectively credited as "Son of a Gunfighter" and "Daughter of Son of a Gunfighter". Zoë Bell, Michael Bowen, Robert Carradine, Jake Garber, Ted Neeley, James Parks, and Tom Savini play Candyland trackers. Jacky Ido, who played Marcel in Tarantino's 2009 film Inglourious Basterds, makes an uncredited appearance as a slave. Michael Parks as Roy and John Jarratt as Floyd, alongside Tarantino himself in a cameo appearance as Frankie, play the LeQuint Dickey Mining Company employees. Tarantino also appears in the film as a masked Bag Head named Robert.
