- Catch-22 was adapted into a feature film of the same name in 1970, directed by Mike Nichols. Alan Arkin portrayed Capt. Yossarian, with an ensemble cast including Art Garfunkel as Nately, Jon Voight as Milo Minderbinder, Orson Welles as General Dreedle, and Martin Balsam as Colonel Cathcart, amongst many others.
- A pilot for a comedy series based upon Catch-22 was made and televised in 1973, with Richard Dreyfuss in the starring role of Yossarian.
- Catch-22 play: Aquila Theatre produced a stage adaptation of Catch-22, based on Heller's 1971 stage adaption. It was directed by Peter Meineck. This production toured the US in 2007/8 with a Bexhill on Sea production in the fall of 2008.
- A six-episode miniseries produced by, and co-starring, George Clooney was picked up by Hulu for a straight-to-series order. It streamed on May 17, 2019. It was also broadcast by Channel 4 in the United Kingdom. Kyle Chandler portrays Colonel Cathcart and Christopher Abbott portrays Yossarian.
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