- Morocco
- Brad Pitt as Richard Jones
- Cate Blanchett as Susan Jones
- Mohamed Akhzam as Anwar
- Peter Wight as Tom
- Harriet Walter as Lilly
- Michael Maloney as James
- Driss Roukhe as Alarid
- Boubker Ait El Caid as Yussef
- Said Tarchani as Ahmed
- Mustapha Rachidi as Abdullah
- Abdelkader Bara as Hassan
- Wahiba Sahmi as Zohra
- Robert Fyfe as Tourist Number 14
- United States/Mexico
- Adriana Barraza as Amelia Hernández
- Gael García Bernal as Santiago
- Elle Fanning as Debbie Jones
- Nathan Gamble as Mike Jones
- Clifton Collins, Jr. as Police Officer at Mexican border.
- Michael Peña as Officer John
- Japan
- Rinko Kikuchi as Chieko Wataya
- Kōji Yakusho as Yasujiro Wataya
- Satoshi Nikaido as Detective Kenji Mamiya
- Yuko Murata as Mitsu
- Shigemitsu Ogi as Dentist Chieko attempts to seduce.
- Ayaka Komatsu as Bikini Model in TV Commercial (uncredited).
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