The book has been referenced in a number of media including Chuck Palahniuk's novel Damned,[17] television shows such as Ted Lasso[18][19] and The Simpsons,[20] South Park,[21]The Venture Bros. television show[22] and the television series Lost.[23]
The book is also referenced in the film Deadpool,[24] Chelsea Handler's book, Are You There, Vodka? It's Me, Chelsea, in 2008.,[25] and Ellen Coyne's Are You There God? It's Me, Ellen, in 2020.[26]
Other television references have included Family Guy,[27] Supernatural,[28] and Bob's Burgers.[29]
Captain Underpants and the Perilous Plot of Professor Poopypants, by Dav Pilkey, references the book in a chapter title, after George and Harold's names are legally changed to Fluffy Toiletnose and Cheeseball Wafflefanny: "Are You There, God? It's Us, Fluffy and Cheeseball."
