- Austin Sloper - Prestigious American physician.
- Catherine Sloper - Austin's wife, née Catherine Harrington.
- Catherine Sloper, Ms - Austin and Catherine's daughter.
- Lavinia Penniman - Austin's sister.
- Elizabeth Almond - Austin's sister.
- Jefferson Almond - Elizabeth's husband, a prosperous merchant.
- Marian Almond - Jefferson and Elizabeth's daughter.
- Morris Townsend - Ms. Catherine's fiancé, abhorred by Austin.
- Arthur Townsend - Morris' cousin, Marian's fiancé.
- Mrs. Montgomery - Morris' widow sister.
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